Synthesis and Biological Activities of Pyrazino[1,2-a]indole and Pyrazino[1,2-a]indol-1-one Derivatives

This review concerns the synthesis and biological activities of pyrazino[1,2-a]indoles pyrazino[1,2-a]indol-1-ones reported since 1997 discovery activity pyrazinoindole derivatives. In first part, we presented synthetic routes that have been from a methodological point view to access unit according cyclization reactions using or not metal catalysts. Then, syntheses neuropsychiatric, auto-immune, anti-infectious anti-cancer properties pyrazinoindoles were detailed. second main accesses pyrazinoindol-1-one substrates Michael reactions, metal-catalyzed metal-free reactions. The anti-cancer, anti-infectious, anti-allergenic neuropsychiatric pyrazinoindolones next described discussed.